This website also contains material copyrighted by 3rd parties. DDAVP is used for a number of different health issues, but for diabetes insipidus, it is primarily used as a urine concentrator.
One option for CDI management is a Continuous Vasopressin Infusion (CVI). Secondary nephrogenic diabetes insipidus as a complication of inherited renal diseases.
The mechanism of action of NSAIDs is not known, but these agents may act by inhibiting prostaglandin synthesis.Inhibition of prostaglandin synthesis reduces the delivery of solute to distal tubules, reducing urine volume and increasing urine osmolality.
Fujiwara TM, Bichet DG.
Clinical predictors of diabetes insipidus after transcranial surgery for pituitary adenoma. Desmopressin is a synthetic analogue of ADH with potent antidiuretic activity but no vasopressor activity.Vasopressin has vasopressor and ADH activity.
Median vasopressin dosing was 0.5 Units/hour. Patients with central diabetes insipidus respond to treatment with vasopressin or its synthetic analogue, desmopressin; however, caution should be utilized in treating infants with vasopressin or analogues-infants can be treated successfully with fluids alone. Free PMC article Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, Stalla GK, Agha A. Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review. 2004 Apr;24(4):541-5. doi: 10.1592/phco.24.5.541.33348.Papadopoulos G, Sintou E, Siminelakis S, Koletsis E, Baikoussis NG, Apostolakis E.J Cardiothorac Surg. 1974 Apr 20;104(16):579-82.J Neurosurg. A ten-year follow-up study of treatment outcome of craniopharyngiomas. It may induce mild volume depletion and cause proximal salt and water retention, thereby reducing flow to the ADH-sensitive distal nephron. Diseases & Conditions Wolters Kluwer Trepiccione F, Christensen BM. 2013 May;57(3):241-7. doi: 10.4103/0019-5049.115599.
In addition, the 2 agents are synergistic with respect to antidiuresis. Unable to load your collection due to an error
This case allows for speculation into predisposing risk factors for this phenomenon including preexisting neurological disease.Central diabetes insipidus (CDI) is characterized by deficient secretion of vasopressin, a hormone produced in the hypothalamus and secreted from the posterior pituitary gland. Evaluation was notable for hyponatremia [serum sodium 129 mmol/L (reference range 133–145 mmol/L)] and Vasopressin is a commonly used agent in intensive care units for treatment of vasodilatory shock. 1969:Suppl 1:43-66.Shukla A, Alqadri S, Ausmus A, Bell R, Nattanmai P, Newey CR.Case Rep Endocrinol.
It increases water resorption at collecting ducts (ADH effect). Familial forms of diabetes insipidus: clinical and molecular characteristics. Vande Walle J, Stockner M, Raes A, Nørgaard JP. 117648-overview
To date, very few reports of diabetes insipidus after discontinuation of vasopressin infusion have been published; the majority of previous reports describe … All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. Ferenchick H, Cemalovic N, Ferguson N, Dicpinigaitis PV.Crit Care Med.
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