Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study. The ability to distinguish characteristics of a rash, including morphology, distribution, and configuration, is critical to forming the differential diagnosis. In addition, habits such as smoking, alcohol consumption, and even long-term use of caffeinated drinks may contribute to oral dryness or the perception of dryness.General drug classes that are strongly associated with xerostomia include antidepressants and antipsychotics, antihypertensives, antihistamines, and anticholinergics.Unfortunately, these associations are confounded by the fact that xerostomia is a subjective complaint, and some patients who report oral dryness may have apparently normal salivary gland function.
Conklin RJ. Erythema multiforme due to Mycoplasma pneumoniae infection in two children. Drug-induced lupus erythematosus 5. 2. Lerch M, Berard F, Fixed drug eruption presents as one or more localised skin lesions that recur with repeated drug exposure in the same location. Bickle K, Obara K, Masuzawa M, Amoh Y. Terziroli Beretta-Piccoli B, 2014. Adverse drug events in the oral cavity. The number of involved sites may increase over time. Examination of the periphery of lesions reveals hyperpigmentation of the skin.
Document any history of previous adverse reactions to drugs or foods 3 A number of malignant neoplasms, such as multiple myeloma, carcinoma of the breast, and carcinoma of the prostate, have a recognized propensity for skeletal involvement. Please confirm that you would like to log out of Medscape. Odom RB, James WD, Berger TG, eds. Fixed drug eruption (FDE) is a cutaneous reaction that occurs most commonly with RMP, and rarely with INH and PZA. A study of 48 patients with recurrent erythema multiforme reported an average of six episodes per year.Persistent erythema multiforme is a rare condition.Erythema multiforme is diagnosed clinically, based on the patient's history and physical examination. Oral lichenoid drug eruptions. Casey CG, Pavlović MD,
Erythema multiforme-like lesions associated with lesional infiltration of tumor cells occurring with adult T-cell lymphoma/leukemia. Erythema multiforme: a review and contrast from Stevens-Johnson syndrome/toxic epidermal necrolysis. If oral ulcers are present, local anesthetics, topical glucocorticoids, and antacids may be useful to control pain.Urticaria, or hives, is a common cutaneous lesion characterized by a wheal-and-flare reaction.
Deepak Kamat, MD, PhD, FAAP, is a Professor of Pediatrics, Vice Chair of Education, Department of Pediatrics, Wayne State University; and the Designated Institutional Official, Children's Hospital of Michigan.Address correspondence to Eric D. Schadler, BS, NorthShore University Health System, 9933 Woods Drive, Suite 100, Skokie, IL 60077; email:
Cutan Ocul Toxicol . Leigh IM. Tonnesen MG. Other patients whose mouths appear to be clinically dry may have no complaints. The tongue and oropharyngeal tissues can also be affected, with a potentially fatal outcome.Epithelial necrosis and ulceration may result from direct application of over-the-counter medications such as aspirin, hydrogen peroxide, potassium tablets, and phenol-containing compounds to the mucosa.
Most reactions are due to the following medicines.Sponsored content: melanomas are notoriously difficult to discover and diagnose.DermNet NZ does not provide an online consultation service. Int J Dermatol. Roark TR, As with the type I reactions, the lips are the most typical site of involvement. 25(1):1-11. Generalized bullous fixed drug eruption after the influenza vaccine. Prins C. Clinically, the oral lesions of drug-induced LE may simulate those of erosive lichen planus, with irregular areas of erythema or ulceration bordered by radiating keratotic striae.
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