Propranolol hepatic impairment naprosyn


In patients with severe liver disease (e.g. If patient continues to smoke, dosage of the beta blocker may need to be increased or a cardio-selective beta blocker may be more appropriate.As with all other drugs, propranolol should not be given in pregnancy or lactation unless its use is essential. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. (ii) Surface printed 20µm hard temper aluminium foil with 5-6g/MPack sizes: 28, 30, 50, 56, 60, 84, 90, 100, 112, 120, 168, 180, 250, 500, 1000.To bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. • Patients prone to hypoglycaemia, e.g. Discussion. Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia during use of NAPROSYN Suspension [see Drug Interactions ]. It allows continued monitoring of the benefit/risk balance of the medicinal product.

Propranolol is widely and rapidly distributed throughout the body with highest levels occurring in the lungs, liver, kidney, brain and heart. Caution should be exercised when starting treatment and selecting the initial dose.As with other beta-adrenoceptor blocking agents, treatment should not be discontinued abruptly. In cases of overdose or extreme falls in the heart rate or blood pressure, treatment with propranolol must be stopped. With concurrent diuretic or other antihypertensive drugs a further reduction of blood pressure is obtained.The starting dose is 40 mg two to three times daily, increasing by the same amount at weekly intervals according to the patient response.
It has been studied mainly in indomethacin. Continue typing to refine. Any unused product or waste material should be disposed of in accordance with local requirements.Sage House, 319 Pinner Road, North Harrow, Middlesex, HA1 4HF, UKTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. The patient may be protected against vagal reactions by the intravenous administration of atropine.Since the half-life may be increased in patients with significant hepatic or renal impairment, care should be taken when starting treatment and selecting the initial dose.Propranolol should be used with caution in patients with decompensated cirrhosis.Liver function will deteriorate in patients with portal hypertension and hepatic encephalopathy may develop. Patients should be followed during withdrawal especially those with ischaemic heart disease.

Psoriasis may be aggravated by the use of beta adrenoreceptor blocking drugs. When suggestions are available use up and down arrows to review and ENTER to select. due to prolonged fasting or restricted counter regulatory reserve.- although contraindicated in uncontrolled heart failure (see section 4.3), may be used in patients whose signs of heart failure have been controlled. In addition, adverse effects (especially hypoglycaemia and bradycardia in the neonate and bradycardia in the foetus) may occur. Breast feeding is therefore not recommended following administration of these compounds.Fertility: No relevant data on effect of fertility in humans is available.Propranolol has no or negligible influence on the ability to drive and use machines. Therefore, propranolol should be used with great caution in conditions such as Raynaud's disease/syndrome or intermittent claudication. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme. The sudden withdrawal of beta-receptor antagonists may result in severe exacerbation of angina pectoris, acute myocardial infarction, sudden death, malignant tachycardia, sweating, palpitation and tremor. The combination with proproanolol should be avoided, especially in patients with cardiac decompensation. The dosage should be withdrawn gradually over a period of 7 to 14 days. Hypotensive effect may be enhanced when propranolol is taken with diuretics, methyldopa or levodopa.Prazosin or other alpha-adrenoreceptor blockers may potentiate postural hypotension, tachycardia and palpitations. Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. QRS complex prolongation, ventricular tachycardia, first to third degree AV block, ventricular fibrillation or asystole may also occur. One of the pharmacological actions of propranolol is to reduce the heart rate; in the instance when symptoms may be attributable to slow heart rate, the dose may be reduced.Beta adrenoceptor blocking drugs may cause a more severe reaction to a variety of allergens, when given to patients with a history of anaphylactic reaction to such allergens.
There have been some reports suggesting that treatment with propranolol may increase the risk of developing hepatic encephalopathy.Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine as it contains lactose.Propranolol 10mg tablets contain carmoisine (E122) which may cause allergic reactions.Care should be taken in the parenteral administration of preparations containing adrenaline Care should be taken when using anaesthetic agents with propranolol. Continuation of beta-blockade reduces the risk of arrhythmias during induction and intubation, although there may be an increased risk of hypertension.

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