Theophylline controls symptoms of asthma and other lung diseases but does not cure them. Do not change your dose or dosing schedule without your doctor's advice.Theophylline doses are based on weight in children. The concentration of Theophylline in breast milk is about equivalent to the maternal serum concentration. Some side effects can be serious Stop taking Voltarol Tablets and tell your doctor straight away if you notice:
Your doctor may occasionally change your dose. In general, these recommendations should serve as the upper limit for dosage adjustments in order to decrease the risk of potentially serious adverse events associated with unexpected large increases in serum Theophylline concentration.Children (6-15 years) and adults (16-60 years) without risk factors for impaired clearance.Patients With Risk Factors For Impaired Clearance, The Elderly (>60 Years), And Those In Whom It Is Not Feasible To Monitor Serum Theophylline Concentrations:Table VI. * Refer to PRECAUTIONS, Drug Interactions for information regarding table. In the first study (Study #1 - Shanon, Ann Intern Med 1993; 119:1161-67), data were prospectively collected from 249 consecutive cases of Theophylline toxicity referred to a regional poison center for consultation. Starting or stopping St. John's wort can affect your blood levels of theophylline.Many drugs can affect theophylline. To be sure you are using the correct dose, your blood will need to be tested often.Avoid driving or hazardous activity until you know how theophylline will affect you. Table I. Continue to take theophylline even if you feel well. Many drugs can interact with theophylline.You should not use theophylline if you are allergic to it.Tell your doctor if you drink alcohol, or if you smoke or have recently quit Also tell your doctor if you have been sick with a high fever (102 degrees or higher) for 24 hours or longer.Tell your doctor if you are pregnant or breastfeeding.Do not give theophylline to a child without medical advice.Follow all directions on your prescription label and read all medication guides or instruction sheets. Starting or stopping St. John's wort can affect your blood levels of theophylline. Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear L.A.-130, Aerolate JR, Theolair-SR, Theoclear L.A.-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCapWe comply with the HONcode standard for trustworthy health information - You may report side effects to FDA at 1-800-FDA-1088.Sometimes it is not safe to use certain medications at the same time. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their healthcare professional. Mean and range of total body clearance and half-life of Theophylline related to age and altered physiological states.¶Special Populations (See Table I for mean clearance and half-life values):If the total daily dose is not appropriately reduced in the presence of these risk factors, severe and potentially fatal Theophylline toxicity can occur.When Signs or Symptoms of Theophylline Toxicity Are Present:Whenever a patient receiving Theophylline develops nausea or vomiting, particularly repetitive vomiting, or other signs or symptoms consistent with Theophylline toxicity (even if another cause may be suspected), additional doses of Theophylline should be withheld and a serum Theophylline concentration measured immediately.The healthcare professional should not assume that a drug does not interact with Theophylline if it is not listed in Table II** Average effect on steady-state Theophylline concentration or other clinical effect for pharmacologic interactions. In the second study (Study #2 - Sessler, Am J Med 1990;88:567-76), data were retrospectively collected from 116 cases with serum Theophylline concentrations >30 mcg/mL among 6000 blood samples obtained for measurement of serum Theophylline concentrations in three emergency departments. )Monitoring and treatment should be continued until the serum concentration decreases below 20 mcg/mL.Serum Concentration >20<30 mcg/mL (with manifestations of Theophylline toxicity)Serum Concentration >30 mcg/mL in patients <60 years of ageSerum Concentration >30 mcg/mL in patients > 60 years of age.The dose of Theophylline must be individualized on the basis of peak serum Theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects.Application of these general dosing recommendations to individual patients must take into account the unique clinical characteristics of each patient. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).Your dose and the number of times you take theophylline daily will depend on the reason you are taking this medication.Follow your doctor's instructions about whether to take your medication with food or on an empty stomach.Your dose needs may change if you are ill, or if you switch to a different brand, strength, or form of this medicine.
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