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Overall, exclusivity loss in one or more developed markets will impact seven of the top 10 leading prescription drugs, including Lipitor, Plavix, Advair Diskus, Crestor, and Nexium.Source: IMS Institute for Healthcare Informatics.

A Jobson publication [Internet].

Even with a black box warning advising against use during pregnancy, there is huge interest in the potential of the product; over 90 clinical trials have been or are being conducted to investigate its use in various patient groups, drug combinations and for other disease states.Genzyme’s doxercalciferol, used to maintain consistent serum concentrations of vitamin D hormone, is approved for secondary hyperparathyroidism, and was acquired when the firm bought Bone Care International to gain products for kidney disease. Sorry, your blog cannot share posts by email. Its cost and inconvenient dosing regimen are factors behind its use as a reserve, for “salvage” therapy in patients with multi-drug resistant HIV.Oxycontin (oxycodone HCI), an opioid for pain management, earned $2.8 billion in sales in 2011 for its U.S. manufacturer, Purdue Pharma LP.AcipHex (rabeprazole sodium), for heartburn associated with acid reflux disease, manufacturer: Eisai Inc. and Janssen Pharmaceuticals, Inc.Zometa (zoledronic acid) injection is a treatment for hypercalcemia of malignancy caused by high calcium blood levels due to cancer; $1.5 billion in global sales in 2010. In addition to being in clinical trials for various combinations, dosage rates, and administration strategies in the mitigation of MS, the drug is now also being studied for macular degeneration and Crohn’s Disease.Gleevec (imatinib mesylate) is a treatment for chronic myeloid leukemia (CML)and gastrointestinal stromal tumor (GIST). It is used in the treatment of chronic hepatitis B infection and fetched almost $1.4 billion in revenues for the firm in 2012. The agency believes that the patent is this basic structure of the compound, a number of new drugs will enter the market next year. Boehringer Ingelheim reported sales of $965 million in 2010.Zyvox (linezolid) is an antiviral manufactured by Pfizer. I got what I wanted on your blog. In 2010, global sales reached $4.6 billion.Included here because of its original patent expiration in 2014, Bristol-Myers has won a pediatric exclusivity extension for aripiprazole until April, 2015…unless Teva prevails in its patent challenge initiated in 2007. However its market share has been declining due to competition and its exclusion from the list of preferred treatment options in some of the U.S. Department of Health and Human Services’ guidelines. Great contribution to the Pharma industryPlease add me to mailing list re updates on Product expirations.

Relevant and specific. Cited 2014 September 10; Available from: URL:From now until 2015, at least 13 blockbuster drugs are scheduled to lose their patent protection. Known as Relpax, which is marketed by Pfizer, the patent expiration for Eletriptan Hydrobromide is on December 26, 2016 (Patent Use Code U – 876 – TREATMENT OF MIGRAINE WITH OR WITHOUT AURA). Registered in England and Wales. Searle had already prevailed in a patent suit with The University of Rochester, and with Vioxx’s market withdrawal in 2004, Celebrex enjoyed a large market share, even with a clinical trial underway investigating the cardiovascular risks now described in a black box warning. Finally, esomepazole carries two patents not expiring until 2018, and the trade press has wondered if these are an ace up AstraZeneca’s patent lawyers’ sleeves.Cymbalta (duloxitine HCI), manufactured by Eli Lilly, is for the treatment of depression, generalized anxiety disorder, diabetic nerve pain, fibromylagia and chronic musculoskeletal pain. De Ruiter J, L Holston. U.S. sales were growing by double digits annually to reach $647.6 million in 2011.Oplana ER (oxymorphone HCI), an opioid agonist approved for management of moderate to severe pain, manufactured by Endo Pharmaceuticals Inc. Factors like increasing life expectancy and high incidence of cancer are bound to act as major growth drivers.Several brands of Fentanyl are nearing patent expiration as well. On April 20, 2018 Lazanda will reach its patent expiration. Its blockbuster drug for anemia, Epogen, which had a sale of about  $2.5 billion (12,500 crore) in 2008, will lose its patent in 2013.Enfuvirtide therapy costs an estimated US$25,000 per year in the United States.

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