The healthcare provider will monitor the condition and reduce the dosage of diazepam accordingly. ; Mania: Initial dose is 25 mg/kg/day, increasing as rapidly as possible to achieve therapeutic response or desired plasma level .The maximum recommended dosage is 60 mg/kg/day (2.1, 2.2). Report major side effects to your doctor immediately, which can include red or purple spots on skin, swelling or pain in joints, bruising, drowsiness, vomiting, change in mental status, drop in body temperature, fever, rash, hives, mouth sores, peelings of skin, swelling of face, and trouble swallowing or breathing. Depakote ER is intended for once-a-day oral administration.
When converting from divalproex delayed-release tablets (Depakote) to divalproex extended-release tablets (Depakote ER), administer the dosage of Depakote ER once daily at a dose 8% to 20% higher than the total daily dose of Depakote. 2002 Divalproex sodium (brand name Depakote) is a drug that is FDA-approved to treat various types of seizures, manic episodes associated with bipolar disorder, and to help prevent migraines . 2010
1142187-overview provider for the most current information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information. Mean Depakote doses for completers in this study were 1,116, 1,683, and 2,006 mg/day at Days 7, 14, and 21, respectively. Find patient medical information for Depakote Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Individual plans may vary Depakote ER: 500 mg PO qDay for 7 days; based on patient response, may increase and adjust dose to 500-1000 mg/day. DEPAKOTE can cause serious side effects, including: Serious liver damage that can cause death, especially in children younger than 2 years old. Always consult your doctor about your medical conditions. 2002 Indicated for treatment of manic episodes associated with bipolar disorder.
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Drugs Depakote has no habit-forming potential, but it is not recommended that you discontinue use of the drug before talking with your doctor, as withdrawal symptoms can occur. ; Complex Partial Seizures: Start at … You can also report side effects to the FDA at 1-800-FDA-1088 or online.This information is not designed to replace a physician's independent judgment about the appropriateness or risks of a procedure for a given patient. ; must be done by the patient herselfAlthough available studies have methodological limitations, the weight of evidence supports a causal association between valproate exposure Contraindicated for use in prophylaxis of migraine headaches in women who are pregnant and in women of childbearing potential who are not using effective contraception; for epilepsy or bipolar disorder, drug should not be used to treat women who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptableWomen with epilepsy who become pregnant while taking valproate should not discontinue therapy abruptly, as this can precipitate status epilepticus with resulting maternal and fetal hypoxia and threat to life; discontinuation of the drug may be considered prior to and during pregnancy in individual cases if seizure disorder severity and frequency do not pose serious threat to patientMaternal valproate use during pregnancy for any indication increases risk of congenital malformations, particularly neural tube defects including spina bifida, but also malformations involving other body systems (e.g., craniofacial defects including oral clefts, cardiovascular malformations, hypospadias, limb malformations)Risk is dose-dependent; a threshold dose below which no risk exists cannot be established; valproate polytherapy with other AEDs has been associated with increased frequency of congenital malformations compared with AED monotherapy; risk of major structural abnormalities is greatest during first trimester; however, other serious developmental effects can occur with valproate use throughout pregnancyThere have been reports of hypoglycemia in neonates and fatal cases of hepatic failure in infants following maternal use of valproate during pregnancyPregnant women taking valproate may develop hepatic failure or clotting abnormalities including thrombocytopenia, hypofibrinogenemia, and/or decrease in other coagulation factors, which may result in hemorrhagic complications in the neonate including deathEvidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases risk for congenital neural tube defects in general population; not known whether risk of neural tube defects or decreased IQ in offspring of women receiving valproate is reduced by folic acid supplementation; dietary folic acid supplementation both prior to conception and during pregnancy should be routinely recommended for patients using valproateThere have been reports of male infertility coincident with valproate therapy; in animal studies, oral administration at clinically relevant doses resulted in adverse reproductive effects in malesDrug is excreted in human milk; data in the published literature describe presence of valproate in human milk; there are no data to assess effects of drug on milk production or excretionDevelopmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from drug or from underlying maternal conditionMonitor breastfed infant for signs of liver damage including jaundice and unusual bruising or bleeding; there have been reports of hepatic failure and clotting abnormalities in offspring of women who used valproate during pregnancyA: Generally acceptable.
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