If the muscle pains are tolerable with or without a CK elevation less than 10 times the upper limit of normal, the Muscle Panel recommends that statin therapy be continued at the same dose or a reduced dose. Your doctor will likely also test your blood for increased creatine kinase (CK) levels—an indicator of rhabdomyolysis. Another theory is that statins can potentially interfere with the production of CoQ10, a coenzyme in the muscles.
So, if your pain is localized to only one area of your body, then it’s probably related to something else. However, if your only symptoms are pain and/or a minor increase in CK blood levels, your doctor may decide that the benefits of continuing with statin therapy outweigh the cons. Furthermore, studies have also shown that people with Reduction in mitochondrial coenzyme Q10 (CoQ … While statins are proven to help reduce cholesterol, they come with a variety of risks and side effects. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Vitamin D is mainly produced in the skin from sun exposure. The most effective treatments are to . The symptoms usually resolve rapidly (within a few days to weeks) after withdrawal of statin therapy. 2017. Statin drugs markedly reduce low-density lipoprotein cholesterol and consequently the incidence of cardiac events. Start reading and start saving! SAMS can vary in frequency and severity. When the drug is removed from the cells, it does not appear to cause muscle damage. This usually effects the larger muscles of the body such as parts of the back or thighs. On the other hand, many have theorized that since both vitamin D and statins are metabolized by the same enzyme in the liver, the use of statins could delay metabolism of vitamin D, thus increasing levels in the blood.Clinical trials and various other studies and reports have yielded mixed results on muscle pain in statin users with low compared to high levels of vitamin D. A large analysis of these trials showed that more studies resulted in statin users having higher levels of vitamin D on average. Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved Any side effects should be attempted to be overcome before giving up on the statin and assuming it is the cause.Gregory, Philip J.
Golomb BA, Verden A, Messner AK, Koslik HJ, Hoffman KB. Ⓒ 2020 About, Inc. (Dotdash) — All rights reservedSide Effects of Statin Drugs That Can Affect Your MusclesHow Different Drugs Can Help Lower Your CholesterolThe Potential Risks of Cholesterol Drugs Zetia and VytorinStatin Drugs May Not Be Beneficial for Some Older AdultsWhat You Should Know About Statin Drug InteractionsHyperlipidemia: Symptoms, Causes, Diagnosis, and TreatmentHow Zocor (Simvastatin) Works to Lower Your Cholesterol One chart review showed that returning vitamin D levels to a sufficient level before a rechallenge in statin users who had experienced muscle pain, increased their tolerability to statins.Some studies have given vitamin D supplements to statin users experiencing muscle pain. Muscle problems related to statin therapy usually begin within a few weeks to a few months after beginning treatment. Millions of Americans take statins because they effectively target all aspects of one's Jennifer Moll, MS, PharmD, is a pharmacist actively involved in educating patients about the importance of heart disease prevention. In general, muscle symptoms directly due to a statin drug cause diffuse muscle aches.
Statins are among the most commonly prescribed medications in the country. 10 Mar. The statin users with higher levels of vitamin D did not have higher risk for muscle pain compared with non-statin users.When a patient experiences what is believed to be the side effect of a drug, they are often taken off of the drug to see if the symptoms resolve. It is also more common in people taking a variety of other medications, including Lopid (gemfibrozil), as well as steroids, cyclosporine, or niacin. In rare cases, the impact of these drugs on the muscles can be serious. While statin-related myalgia, myositis, and rhabdomyolysis will resolve once you stop taking statins, rhabdomyolysis may result in irreversible muscle damage. You develop: –muscle pain all over without weakness
The muscles may feel stiff or sore like the feeling after working out. Dr. Ali is also an award-winning writer.
The liver and kidneys are responsible for activating the vitamin D which then plays a role in facilitating intestinal absorption of essential nutrients as well as balancing bone health homeostasis. The exact cause of this phenomenon is not completely understood, but many researchers have hypothesized that vitamin D levels may play a role.
If you have started statins and experience muscle pain, see your doctor. Vitamin D deficiencies often present with similar muscle pain as those found as a side effect in statins.Some researchers have theorized that statins could reduce vitamin D levels because certain types of cholesterol carry vitamin D and when the cholesterol is reduced, less vitamin D could be transported. Truven Health Analytics, Inc. Ann Arbor, MI. Group 1 was 1.21 times more likely to develop muscle pain than group 4. Approximately 1-2% of patients on statins report experiencing muscle pain.
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