3075 structure-activity relationships and mechanism of action The features of the bisphosphonate molecule necessary for biological activity were well defined in the early studies. Sorry, this question is for Question Complexity It also highlights the newer developments in the field of study of bisphosphonates. The first three mechanisms will lead to a decrease in the number of … (OBQ11.223) A 10-year-old child falls from a standing height and sustains the injury shown in Figure A. Although nitrogen-containing bisphosphonates can induce osteoclast apoptosis, this is not necessary for their inhibition of bone resorption.
Question Complexity Mechanism of Action of Simple Bisphosphonates Simple Bisphosphonates are Metabolized into ATP Analogues . J Clin Invest. The concentrations of etidronate required to inhibit bone resorption … Bisphosphonates can now be distinguished based on their molecular and cellular mechanisms of action. L 2 B Question Session⎪Bisphosphonates Type in at least one full word to see suggestions list B Please enable it to take advantage of the complete set of features! Type in at least one full word to see suggestions list 1997 Feb;29(1):55-62. doi: 10.3109/07853899708998743.Am J Med Sci. Question Complexity There is now general agreement that the final target of bisphosphonate action is the osteoclast.
Type in at least one full word to see suggestions list Question Complexity 445 Mechanism of action for zoledronic acid/zoledronate (Zometa). Question Complexity Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson DD, Golub E, Rodan GA. Bisphosphonate action. Type in at least one full word to see suggestions list
B QID: Question Importance 2020 Aug 29;15(1):137. doi: 10.1007/s11657-020-00799-0.Nanomaterials (Basel). QID: QID: Date Type in at least one full word to see suggestions list Question Importance L 2 L 3 (OBQ05.30) Conversion of drug into a non-functioning ATP-analogueInhibition of geranylgeranyl diphosphate synthase (GGPPS)Downregulation of the undecaprenyl diphosphate synthase (UPPS) pathwayAny effect can be counteracted by taking calcium supplementsCreating toxic analog of adenosine triphosphate that targets mitochondriaPost-translational carboxylation of vitamin K dependent proteinsInhibits farnesyl diphosphate synthase in osteoclasts
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