And which one actually works?. It's not the antidepressant that is causing the weight gain directly – it's the fact that it's treating someone's low mood, which was causing loss of appetite. Prozac is also approved by the U.S. FDA for the treatment of bulimia nervosa (Zoloft is not) – whereas Zoloft is also approved by the U.S. FDA for the treatment of premenstrual dysphoric disorder (PMDD), post-traumatic stress disorder (PTSD), and social anxiety disorder (Prozac is not).Each of these medications are frequently prescribed as “off-label” interventions for the management of neuropsychiatric conditions. Prozac is metabolized in the liver by cytochrome P450 isoenzymes, most notably, CYP2D6 and CYP2C19. Despite the fact that both Prozac and Zoloft are broadly classified as SSRIs (selective-serotonin reuptake inhibitors), they contain different chemicals (fluoxetine vs. sertraline) and do not exert identical effects within the body.As you can read based on the chart below, Prozac and Zoloft are similar in some ways and different in others. Weight gain is a possible side effect of nearly all antidepressant drugs. There are a lot of TV commercials out there for anxiety medications. If you have a preference for one medication over the other – report the reason(s) as to why you have this preference.Possible reasons for preferring one drug over another include: greater efficacy; fewer unwanted side effects (e.g. Antidepressants have long been associated with weight gain. (To a lesser extent, CYP2B6 and CYP2C9 are suggested as being involved in Prozac metabolism).CYP2D6 is needed to convert fluoxetine into its only biologically-active metabolite “norfluoxetine.” The bioavailability of Prozac is considered fairly high (~72%) and peak plasma concentrations are attained within 6 to 8 hours of administration.The elimination half-life of Prozac and its primary active metabolite (norfluoxetine) is considered long. Zoloft may be harsher on the stomach, while Prozac is more likely to cause headaches.Both drugs are generally effective and safe, but people taking Prozac or Zoloft should follow up with their doctor to discuss their symptoms and side effects to ensure that they are taking the most effective dosage.If treatment is successful, the doctor will slowly reduce the dosage if possible to eventually stop the medication. A 30-day supply of generic Prozac tablets costs: $4 to $56 (10 mg dose); $30 to $80 (20 mg dose); and $110 to $365 (60 mg dose).Prozac and Zoloft are similar in that they are manufactured in 3 distinct dosages: Prozac is sold in 10 mg, 20 mg, and 40 mg capsules – and Zoloft is sold in 25 mg, 50 mg, and 100 mg tablets. As of 2013, over 41 million prescriptions were written for Zoloft – which made it the most prescribed antidepressant and the second most prescribed psychiatric medication in the United States.Within the past year (2017 to 2018), it appears as though ~38.8 million prescriptions were filled for generic Zoloft (making it the #1 most-prescribed SSRI), whereas ~28.3 million prescriptions were filled for generic Prozac (making it the #2 most-prescribed SSRI) in the United States.
In this way, you could argue that the antidepressant isn't strictly responsible for weight gain – it's just treating the underlying cause of weight loss. Prozac (fluoxetine) is good for treating depression and anxiety. Prozac and Zoloft are two types of antidepressant.
All rights reserved. In fact, appetite is one of the key areas that doctors ask about when they are In these patients when they are started on an antidepressant, their mood improves over the weeks and months of taking the medication and so the poor appetite also improves and as a result their weight increases.
Differences in metabolism can be a big deal to persons with genetic polymorphisms that affect cytochrome P450 enzyme expression. A 30-day supply of “brand name” Prozac costs between $912 and $980, whereas a 30-day supply of “brand name” Zoloft costs between $299 and $325.In the event that a patient ends up using generic Prozac tablets (instead of generic Prozac capsules), the cost will far exceed the generic Prozac capsules – and the generic Zoloft tablets. Compare Fluoxetine vs Viibryd head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. However, it is important to understand that everyone responds to antidepressants differently, meaning some people will gain weight while taking certain antidepressants, while others don't.The first thing to realise is that the relationship between antidepressants and weight gain is actually reliant on several factors.If you are taking antidepressants and are concerned about weight gain, it is important that you do not stop taking the medication. The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with a medical doctor.
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